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Fatigue is most commonly related to excess fluid in patients undergoing hemodialysis. In the context of kidney function, when excess fluid accumulates in the body, it can lead to increased blood volume and elevated blood pressure, which places an immense strain on the heart. This may result in symptoms like fatigue, as the body struggles to manage the higher workload and maintain sufficient circulation and oxygenation to tissues.

Moreover, excess fluid can contribute to other complications such as shortness of breath and edema, which can further diminish a patient's energy levels and overall sense of well-being. Understanding the relationship between fluid overload and fatigue is essential for nurses and patient care technicians in monitoring and managing patients effectively during hemodialysis.